Evaluation of Anti-inflammatory Activity of Estragole by Modulation of Eicosanoids Production
نویسندگان
چکیده
Introduction: The estragole (EST) is a phenylpropanoid presents in many aromatic plants used in the folk medicine. Its anti-inflammatory activity was recently reported in the literature and researchers have suggested that it should be related to the inhibition of prostaglandins biosynthesis. Objective: To determine the mechanism of the anti-inflammatory activity exerted by EST. Materials and Methods: A series of experiments was conducted to evaluate the effects of the test compound on carrageenan-induced paw edema in mice, on prostaglandin levels in the inflamed paw tissues, and on cyclooxygenase (COX) and lipoxygenase (LOX) activities. Results: The treatment with EST (200 and 400 mg/kg) significantly reduced the paw edema after subplantar carrageenan injection. Moreover, EST (200 and 400mg/kg) significantly decreased the prostaglandin E2 levels in the inflamed paw tissues four hours after stimuli. However, EST was inactive against the both COX and LOX enzymes. Discussion: It is known that EST suppresses the translocation of nuclear factor κB (NF-κB) to the nucleus of the cells after inflammatory stimuli. The results suggest that EST only interferes with the synthesis of COX-2 isoform, after inflammatory stimuli, by suppression of NF-κB activity, without interferer with the enzymes activities. Conclusion: Our data provide evidence that EST exerts considerable antiinflammatory activity. The mechanism involved in the anti-inflammatory effect of EST may offer promising therapeutic benefits, since EST does not inhibit the COX-1 enzyme and, consequently, does not promote gastric damage.
منابع مشابه
Estragole and methyl-eugenol-free extract of Artemisia dracunculus possesses immunomodulatory effects
Objective: Some evidence suggests that chronic uptake of estragole and methyl-eugenol, found in the essential oil of Artemisia dracunculus (tarragon), may be associated with an increased risk of hepato-carcinogenicity. The present study was conducted to investigate the immumodulatory and anti-inflammatory potentials of estragole and methyl-eugenol free extract of tarragon. Materials and Methods...
متن کاملModulation of Lipopolysaccharide Stimulated Nuclear Factor kappa B Mediated iNOS/NO Production by Bromelain in Rat Primary Microglial Cells
Background: Microglial cells act as the sentinel of the central nervous system .They are involved in neuroprotection but are highly implicated in neurodegeneration of the aging brain. When over-activated, microglia release pro-inflammatory factors, such as nitric oxide (NO) and cytokines, which are critical in eliciting neuroinflammatory responses associated with neurodegenerative diseases. Thi...
متن کاملEvaluation of Anti-inflammatory and Analgesic Activity of Root Extract of Solanum Trilobatum Linn
Methanolic extract of Solanum trilobatum Linn. (MEST) belonging to the family of Solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. The extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in...
متن کاملEvaluation of Anti-inflammatory and Analgesic Activity of Root Extract of Solanum Trilobatum Linn
Methanolic extract of Solanum trilobatum Linn. (MEST) belonging to the family of Solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. The extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in...
متن کامل